TITLE:
Glucose transporters expression in the placental terminal villi of preeclampsia and intrauterine growth retardation complicated pregnancies
AUTHORS:
Elena A. Dubova, Konstantin A. Pavlov, Galina V. Kulikova, Alexander I. Shchegolev, Gennady T. Sukhikh
KEYWORDS:
Preeclampsia; Placenta; GLUT-1; GLUT-3
JOURNAL NAME:
Health,
Vol.5 No.7D,
July
18,
2013
ABSTRACT:
Introduction: Transmembrane
sodium-independent glucose
transporters (GLUTs) play an important role in both placental and fetal development by the providing transplacental glucose transport. Abnormal GLUT-1 and
GLUT-3 placental expression could play a role in such late pregnancy complications development as preeclampsia
and intrauterine growth retardation. Materials
and Methods: Immunohistochemistry was performed to reveal patterns of
GLUT-1 and GLUT-3 expression in the placental terminal villi compartments. Results: GLUT-1 syncytial expression in the terminal villi of severe PE cases (both with and without IUGR) was
significantly lower in compare to control group. We also report about
GLUT-3 both syncytial and endothelial expression in the near term and term
placental terminal villi without significant difference between the study and control groups. Conclusion: other study
should be performed to establish the nature of GLUT-1 downregulation in severe
preeclampsia cases and whether GLUT-3 is expressed in the syncytiotrophoblast
of near term and term placentas or not.