A. C. E. Graziano, V. Cardile, L. Crascì, S. Caggi, P. Dugo, F. Bonina and A. Panico, “Protective Effects of an Extract from Citrus Bergamia against Inflammatory Injury in Interferon-γ and Histamine Exposed Human Keratinocytes,” Life Sciences, Vol. 27, No. 90, 2012, pp. 968-974. doi:10.1016/j.lfs.2012.04.043

has been cited by the following article:

• TITLE: Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process

  AUTHORS: Lucia Crascì, Annamaria Panico

  KEYWORDS: Neoeriocitrin; Naringin; Neohesperidin; Metalloproteinases-13; Cartilage Degradation

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.4 No.3, July 18, 2013

  ABSTRACT: The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.