TITLE:
Diagnostic accuracy of color Doppler in diagnosis of Hepatocellular carcinoma taking histopathology as gold standard
AUTHORS:
Wajid Ali, Kanwal Saba, Nasir Raza Zaidi, Tayyaba Majeed, Mulazim Hussain Bukhari
KEYWORDS:
Hepatocellular Carcinoma; Doppler Sonography; Focal Liver Lesions
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.6,
June
26,
2013
ABSTRACT:
Hepatocellular carcinoma
(HCC) is the fifth most common cancer in the world and the third most common
cause of cancer mortality. Despite the high numbers of patients diagnosed
worldwide, HCC continues to pose challenging clinical problems. Good-quality
ultra sound with careful evaluation of the entire liver can be a screening
examination for HCC in patients at risk. The aim of the study was to determine
the diagnostic accuracy of the Doppler sonography for differentiation of
hepatocellular carcinoma (HCC) from other focal liver lesions by taking
histopathology as a gold standard. It
was a cross-sectional survey, conducted in the Department of Diagnostic
Radiology, King Edward Medical University/Mayo Hospital, Lahore in one year
from 13-12-2010 to 12-12-2011. A total of 70
patients were included in this study with focal lesions on ultrasound
are included while pregnant patients are excluded. After evaluating by Doppler
sonography and doing core biopsy, the patients were sent to the Department of Pathology,
Mayo Hospital for histopathological examination. Histopathology was
assessed for confirmation of positive and negative cases. Mean age of the
patients was 60.9 ± 4.7 years. Out of 70 patients, 47 patients (67.1%) were
male while remaining 23 patients (32.9%) were female. On Doppler sonography 37
cases were positive for hepatocellular carcinoma and 33 cases were negative
while 36 cases were positive and 34 negative on histopathology. On Doppler
sonography, sensitivity (94.4%), specificity (91.1%), diagnostic accuracy
(92.8%), positive predictive value (91.8%) and negative predictive value was
93.9%. We concluded that Doppler sonography
is a useful method for differen-
tiation of
Hepatocellular carcinoma from other focal liver lesions, detection and
characterization of hepatocellular carcinoma.