Article citationsMore>>
Lehman, T.A., Bennett, W.P., Metcalf, R.A., Welsh, J.A., Ecker, J., Modali, R.V., Ullrich, S., Romano, J.W., Appella, E. and Testa, J.R. (1991) p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Research, 51, 40904096.
has been cited by the following article:
-
TITLE:
Biological evaluation of 8-alkyl xanthines as potential cytotoxic agents
AUTHORS:
Renuka Suravajhala, Nitasha Suri, Madhulika Bhagat, Ajit Kumar Saxena
KEYWORDS:
8-Substituted Alkyl Xanthines; Cytotoxicity; Anticancer Agents
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.3,
June
25,
2013
ABSTRACT:
A series of 8-substituted alkyl
xanthines were evaluated in vitro to test the cytotoxocity in cells.
For this experiment, we utilized different mammalian cancer cell lines
primarily representing prostrate and lung. One of the compounds synthesized, viz. 8-tertbutyl caffeine showed potent anticancer activity at low concentrations
against DU145 when compared to adriamycin. Further experiments were carried out to check the cell cycle arrest in
the DU145 cells treated with adriamycin, caffeine and 8-tert butyl caffeine. We
observed that there was an arrest in G1 phase of cell cycle at 24 hours while at
48 hours of incubation, the cells
were constantly distributed (59.71% -70.79%). We conclude that the effect of
8-tertbutyl caffeine is relatively comparable to caffeine whereas in adriamycin
treated cells, we observed the cells underwent G2 arrest. We evaluate the
studies on these effects by showing potent analogues which could be used as promising anticancer agents.
Related Articles:
-
Apichat Asavamongkokul, Pojchong Chotiyarnwonga, Pojchong Chotiyarnwonga, Nednapis Tirawanchai, Saranatra Waikakul
-
Kanako Obayashi, Kayoko Takada, Kazuaki Ohashi, Ayako Kobayashi-Ohashi, Masatomo Maeda
-
Adi Prayitno, Elyana Asnar, Okid Parama Astirin, Dinar Rosmala, Suhartono Taat Putra
-
Leonor Osório Almeida
-
Danny V. Colombara, David Eidsmoe, Joshua E. Stern, Qinghua Feng, Hubert Vesselle, Stephen E. Hawes