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has been cited by the following article:

• TITLE: Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: Trans-[PtCl2(Dimethylamine) (Isopropylamine)]. Application to Biological Samples

  AUTHORS: Carmen S. H. Domínguez, Pedro Hernández

  KEYWORDS: Trans-[PtCl2(Dimethylamine)(Isopropylamine)]; Differential Pulse Voltammetry (DPV); Square Wave Voltammetry (SWV); Biological Fluids; Human Urine

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.4 No.6, June 20, 2013

  ABSTRACT: A square wave voltammetry (DPV) method for trans-Pt[Cl2(Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans-Pt[Cl2(Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of trans-Pt[Cl2(Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with an adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with trans-Pt[Cl2(Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 μg·mL-1 to 10 μg·mL-1 range, with a LOD 91 μg·mL-1 of and a LOQ of 303 μg·mL-1, a RSD 1.10% and Er 0.72%. The optimized method was applied to the determination of trans-Pt[Cl2(Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.