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B. N. Hangalapura, D. Oosterhoff, S. Aggarwal, P. G. Wijnands, R. van de Ven, S. J. Santegoets, M. P. van den Tol, E. Hoojiberg, A. Pereboev, A. J. van den Eertwegh, D. T. Curiel, R. J. Scheper and T. D. de Gruijl, “Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-Avidity Melanoma-Reactive Cytotoxic T Cells by a CD40-Targeted Adenovirus,” Journal of Immunotherapy, Vol. 33, No. 7, 2010, pp. 706-715. doi:10.1097/CJI.0b013e3181eccbd4
has been cited by the following article:
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TITLE:
Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses
AUTHORS:
Kristian M. Hargadon
KEYWORDS:
Melanoma; Tumor Immunotherapy; Dendritic Cell; Tumor Antigen; T Cell; Vaccine; Adoptive Transfer
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.2A,
June
20,
2013
ABSTRACT:
Melanoma is the most aggressive form
of skin cancer and accounts for the vast majority of skin cancer-related
deaths. Its ability to metastasize quickly, often before diagnosis, makes this
cancer difficult to treat with traditional therapies. The identification of
anti-melanoma immune responses in patients and the discovery of tumor antigens
targeted by these immune responses have paved the way for immunotherapy as a
novel approach to treating this cancer. In this review, the major
immunotherapies targeting these melanoma tumor antigens are discussed. The
advantages and limitations of peptide-, protein-, and gene-based vaccination
maneuvers and adoptive cell transfer therapies are emphasized. Recent insights
into melanoma immune evasion strategies are also highlighted, with particular
focus on how our increasing knowledge of tumor/immune cell interactions is
driving the development of novel immunotherapeutic strategies for the treatment
of melanoma.
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