TITLE:
A Comparative Study of Thyroid Hormone and Lipid Status of Patient with and without Diabetes in Adults
AUTHORS:
Hasi Rani Saha, Habiba Khan, Bidhan Chandra Sarkar, Shahidul Alam Khan, Niranjan Kumar Sana, Akira Sugawara, Subhagata Choudhury
KEYWORDS:
NIDDM; IDDM; Glycosylated Hemoglobin; Lipid Profile; Hypo and Hyperthyroidism
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.2,
May
23,
2013
ABSTRACT:
Introduction: Lipid and
thyroid function abnormalities are common in IDDM and NIDDM. Very few studies
have addressed this issue in Bangladesh though Bangladeshi population is very
much susceptible to patient with diabetes. Aims: To study on lipid profile
and thyroid function in IDDM and NIDDM and the effect of glycemic control on
it. Patients and Methods: This was a retrospective study carried out in the Dept. of
Endocrinology, BIRDEM, Dhaka, Bangladesh during the period of
January, 2012 to May, 2012. In this study, population consisted of 120 subjects
(Age between 40 - 72 years; and Sex matched) divided into two groups: patient with
diabetes 60 subjects (male-30, female-30) and patient without diabetes 60
subjects (male-30, female-30). Plasma glucose, HbA1c and serum lipids were measured by enzymatic method. Thyroid hormones were measured by a Chemiluminescent Micro particle Immunoassay
(CMIA).Results: The
statistical significance was evaluated by Student’s t-test,
Correlation-Coefficient test. All Values are given as mean ± SD. The
level of serum TSH in patient with diabetes (3.43 ± 2.71)
was significantly (p 0.05) increased compared to patient without
diabetes subjects (1.98 ± 1.72). TSH levels were positively correlated
with fasting plasma glucose (r = 0.240, p 0.05), serum
cholesterol (r = 0.290, p 0.020) and triglyceride concentration (r = 0.246, p 0.05). On
the other hand, free T4 levels were inversely correlated with
postprandial blood glucose (r =－0.256, p 0.046). Conclusions: It may be
concluded that the lipid and thyroid function abnormalities with others
socio-demographic and biophysical risk factors were more common in patient with
diabetes cases rather than patient without diabetes cases. Therefore, further
prospective studies with larger number of patients are required to strengthen
the observations of the present study.