TITLE:
Comparison of glycemic variability between basal-bolus and premixed insulin therapy
AUTHORS:
Satoru Yamada, Ryo Hirai, Gaku Inoue, Yoshifumi Yamada, Junichiro Irie, Koichiro Atsuda, Toshikazu Yamanouchi
KEYWORDS:
Glycemic Variability; Insulin Therapy; Diabetes; Continuous Glucose Monitoring
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.2,
May
9,
2013
ABSTRACT:
Background: Several
studies have shown that twice-daily injections of premixed insulin analogs
(MIX) could achieve comparable HbA1c levels to basal-bolus (BB) therapy.
However, HbA1c does not necessarily reflect short-term glycemic fluctuations
that may contribute to the onset or progression of diabetic complications.
Therefore, in this study, we compared MIX and BB therapies in terms of their
effects on glycemic variability. Methods:
We performed a crosssectional observational study of patients attending
our outpatient clinics to compare the effects of two insulin regimens on
glycemic variability. We recruited patients treated with MIX or BB with HbA1c
180 mg/dL (t > 180) was significantly shorter with BB
therapy (88 ± 76 min) than with MIX therapy (145 ± 54 min; p