TITLE:
Theory of affinity maturation of antibodies
AUTHORS:
Udo Riss
KEYWORDS:
Affinity Maturation; Somatic Mutation; THz Waves; Antibody; Antigen
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.4A,
April
30,
2013
ABSTRACT:
Based on the theory of long distance interaction between antibodies and antigens we developed a theory of affinity maturation of
antibodies that is based on longitudinale electric waves. Early stage
antibodies show a wide frequency spectrum for antigens and are polyspecific.
After affinity maturation the antibody shows a very narrow band spectrum, the
antibodies become monospecific. The feedback between antibody and antibody
producing cell is done via messenger molecules that are also communicating
with help of longitudinal electric waves. These messenger molecules transfer
information from antibody arms and are informing cells whether the epitopes are
switched on or off. The folding of antibody is done via eigen frequency
resonances.