Article citationsMore>>
Yang, F., Lim, G.P., Begum, A.N., Ubeda, O.J., Simmons, M.R., Ambegaokar, S.S., Chen, P.P., Kayed, R., Glabe, C.G. and Frautschy, S.A. (2005) Curcumin inhibits for- mation of amyloid beta oligomers and fibrils, binds pla- ques, and reduces amyloid in vivo. The Journal of Bio- logical Chemistry, 280, 5892-5901.
doi:10.1074/jbc.M404751200
has been cited by the following article:
-
TITLE:
Curcumin protects against rotenone-induced neurotoxicity in cell and drosophila models of Parkinson’s disease
AUTHORS:
Zhaohui Liu, Tianxia Li, Dejun Yang, Wanli W. Smith
KEYWORDS:
Parkinson’s Disease; Curcumin; Rotenone; Reactive Oxygen Species; Mitochondria; Drosophila
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.2 No.1,
February
18,
2013
ABSTRACT: Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder resulting from a selective loss of dopaminergic neurons. The pathogenesis of PD remains incompletely understood, but increasing evidence from human and animal studies has suggested that oxidative damage contributes to the neuronal loss in PD. In this study, we used rotenone (a mitochondrial complex I inhibitor) based cell and Drosophila models that resemble some key pathological features of PD to test whether curcumin, a potent antioxidant compound, derived from the curry spice turmeric, could protect against rotenone-induced neuronal toxicity. We found that curcumin reduced rotenone induced cell death in SH-SY5Y human neuroblastoma cells and alleviated PD-like symptoms in drosophila via reducing the intracellular and mitochondrial reactive oxygen species (ROS) levels and inhibiting the caspase-3/caspase-9 activity. These results suggest that curcumin is a promising therapeutic compound for PD.
Related Articles:
-
Ivonne Rosales, Laura Salazar, Daniel Luna, Alicia Negrón, Igor Bdikin, Brian J. Rodriguez, Alejandro Heredia
-
Takayasu Kawasaki, Toyonari Yaji, Takayuki Imai, Toshiaki Ohta, Koichi Tsukiyama
-
Yang Li, Fengyuan Zhang, Caroline E. Herron, Ivonne Rosales, Alejandro Heredia, Nicolae-Viorel Buchete, Brian J. Rodriguez
-
Masoud Soheili, Mostafa Rezaei Tavirani, Mahmoud Salami
-
Antti Kurronen, Rea Pihlaja, Eveliina Pollari, Katja Kanninen, Markus Storvik, Garry Wong, Milla Koistinaho, Jari Koistinaho