Proceedings of International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), Tripartite harmonised guideline Q3A (R) Impurities in new drug substances?, 2002.

has been cited by the following article:

• TITLE: Quantitative determination of residual 2-(2-chloroethoxy) ethanol (CEE) in quetiapine fumarate by gas chromatogaraphy

  AUTHORS: Pravish Tiwari, Ravi Yadav, Padmakar A. Sathe, Deepali Gangrade

  KEYWORDS: GC; 2-(2-Chloroethoxy) Ethanol

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.1 No.5, December 30, 2010

  ABSTRACT: A simple and specific gas chromatographic method developed and validated for the determination of 2-(2-chloroethoxy) ethanol in Quetiapine Fumarate. The method is carried out with a flame ionization detector and DB-FFAP capillary column. The linearity was established over a range of 40-150 µg ml-1 and correlation coefficient is more than 0.999.