H. Yoshidome, M. Miyazaki, H. Shimizu, et al., “Obstructive Jaundice Impairs Hepatic Sinusoidal Endothelial Cell Function and Renders Liver Susceptible to Hepatic Ischemia/Reperfusion,” Journal of Hepatology, Vol. 33, No. 1, 2000, pp. 59-67.
doi:10.1016/S0168-8278(00)80160-9
-
TITLE:
Relationship between Serum Hyaluronic Acid Level and Patient Prognosis in Hepatocellular Carcinoma Patients Who Underwent Hepatectomy
AUTHORS:
Atsushi Nanashima, Takafumi Abo, Goushi Murakami, Masaki Kunizaki, Hiroaki Takeshita, Shigekazu Hidaka, Kazuo To, Tomoshi Tsuchiya, Takeshi Nagayasu
KEYWORDS:
Hepatocellular Carcinoma; Hepatectomy; Serum Hyaluronic Acid Level; Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.2A,
February
28,
2013
ABSTRACT:
We examined the relationship between hyaluronic acid (HA) and tumor-related factors after hepatectomy in 158 patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. We examined serum HA levels before hepatectomy by evaluating data for clinicopathological parameters, surgical records, postoperative complications and survival. The mean HA level was 190 ± 202 ng/ml. Patients were divided into 3 groups: group A had serum HA levels less than 50 ng/ml (normal range), group B had levels between 50 and 190 ng/ml, and group C had levels over 190 ng/ml. Group C had a higher rate of poor liver function compared to others. Multiple tumors were significantly more frequent in groups B and C compared to A. The grade of fibrosis and the inflammatory responses were positively correlated with the serum HA level. Postoperative long-term ascites was significantly more frequent in group C compared to others. Although the recurrence rate and the relapse-free period were not significantly related to the serum HA level, the serum HA level was significantly associated with overall survival after hepatectomy (p 0.05). Cox’s multivariate analysis did not show a significant relationship between HA level and survival. Serum HA reflects progression and survival in HCC patients.
Related Articles:
Hepatic Sinusoidal Obstruction Syndrome without Preceding Medical Events
Yukino Kawanami, Riko Kitazawa, Ryuma Haraguchi, Yasuo Ueda, Yukiko Nishi, Kanazu Ariyasu, Yosuke Mizuno, Sohei Kitazawa
DOI:
10.4236/crcm.2016.53019
2,346 Downloads 3,074 Views Citations
Pub. Date:
March
17,
2016
Doppler Ultrasound of Hepatic Vessels in the Diagnosis of Cirrhosis of the Liver in Togo
Lantam Sonhaye, Abarchi Habibou Boube, Abdoulatif Amadou, Bérésa Kolou, Mohaman Djibril, Bidamin Ntimon, Mazamaesso Tchaou, Nouhou Mamoudou Garba, Lama Kègdigoma Agoda-Koussema, Komlavi Adjenou
DOI:
10.4236/ojrad.2018.81007
790 Downloads 2,393 Views Citations
Pub. Date:
March
22,
2018
