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has been cited by the following article:

• TITLE: Heart Rate Variability, Standard of Measurement, Physiological Interpretation and Clinical Use in Mountain Marathon Runners during Sleep and after Acclimatization at 3480 m

  AUTHORS: Ivana Gritti, Stefano Defendi, Clara Mauri, Giuseppe Banfi, Piergiorgio Duca, Giulio Sergio Roi

  KEYWORDS: Heart Rate Variability; Very Low Frequency Fluctuation (VLF,

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.3 No.1, February 27, 2013

  ABSTRACT: Fluctuations in autonomic cardiovascular regulation during exposure to high altitude may increase the risk of heart attack during waking and sleep. This study compared heart rate variability (HVR) and its components during sleep at low altitude and after 30 - 41 hours of acclimatization at high altitude (3480 m) in five mountain marathon runners controlled for diet, drugs, light-dark cycle and jet lag. In comparison to sea level, RR-intervals during sleep at high altitude decreased significantly (P 0.001). The significant increase in sympathetic autonomic cardiovascular modulation at high altitude protects against excessive oxygen deprivation during sleep. Increases in R-R intervals can require longer periods of acclimatization at3480 m to mitigate the effects of altitude/hypoxia on sympathetic tone, thus reducing cardiovascular distress at rest during waking and sleep and probably before during and after athletic performance at altitude.