B. Muller-Hubenthal, M. Azemar, D. Lorenzen, M. Huber, M. A. Freudenberg, et al., “Tumor Biology: Tumour- Associated Inflammation versus Antitumor Immunity,” Anticancer Research, Vol. 29, No. 11, 2009, pp. 4795- 4806.

has been cited by the following article:

• TITLE: Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells

  AUTHORS: Delira Robbins, Wenjuan Li, Katie Humphrey, Yunfeng Zhao

  KEYWORDS: Ref-1; Tumorigenesis; JB6 Cells; Tumor Promotion; Chemoprevention

  JOURNAL NAME: Open Journal of Apoptosis, Vol.1 No.3, October 26, 2012

  ABSTRACT: Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sensitive P+ and promotion resistant P? mouse skin epidermal JB6 cells, we found that Ref-1 expression was only induced in tumor promotion sensitive P+ cells following TPA treatment. Consistent with that, Ref-1 knockdown suppressed skin cell transformation. Interestingly, Ref-1 knockdown suppressed nuclear translocation of NF-kappaB subunit p65, and inhibited production of proinflammatory cytokines. These results suggest Ref-1 may promote early tumorigenesis and serve as a target for chemoprevention.