Galbas, T., Steimle, V., Lapointe, R., Ishido, S. and Thibodeau, J. (2012) MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression. Cytokine, 59, 27-30. doi10.1016/j.cyto.2012.03.015 - References

Browse Menu >>

Browse Subjects >>

Computer Science & Communications

Earth & Environmental Sciences

Social Sciences & Humanities

Why Us? >>

- Open Access
- Peer-reviewed
- Rapid publication
- Lifetime hosting
- Free indexing service
- Free promotion service
- More citations
- Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.

Contact Us >>

customer@scirp.org

+86 18163351462(WhatsApp)

1655362766

Paper Publishing WeChat

Book Publishing WeChat

(or Email:book@scirp.org)

Article citations
More>>

Galbas, T., Steimle, V., Lapointe, R., Ishido, S. and Thibodeau, J. (2012) MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression. Cytokine, 59, 27-30. doi:10.1016/j.cyto.2012.03.015

has been cited by the following article:

TITLE: Cell-type specific regulation of MARCH1 E3 ubiquitin ligase by the anti-inflammatory cytokine IL-10

AUTHORS: Tristan Galbas, Jacques Thibodeau

KEYWORDS: MARCH1; Interleukin-10; MHC-II; Ubiquitin; Antigen-Presenting Cells

JOURNAL NAME: Open Journal of Immunology, Vol.2 No.4, December 31, 2012

ABSTRACT: Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase which targets MHC-II, CD86 and various other molecules for degradation. It is one of the most efficient post-translational regulators of antigen presentation. MARCH1 is expressed in resting immature dendritic cells and B cells but can be induced in other cell types. While activation of most immune cells results in a reduction in MARCH1 gene expression, its anti-inflammatory properties are highlighted by its induction in response to IL-10. Here, we review what is known about the regulation of MARCH1 gene expression in response to IL-10 by various immune cells. We speculate on the role of MARCH1 ininfection, its differential expression pattern and the promise that this E3 ubiquitin ligase holds to influence immune responses and mitigate immune pathologies.