TITLE:
Fatal liver abscess caused by Clostridium perfringens complicated with transarterial chemoembolization
AUTHORS:
Noriaki Sakamoto, Masato Yamaguchi, Takuya Okada, Koji Idoguchi, Eisuke Ueshima, Akhmadu Muradi, Koji Sugimoto
KEYWORDS:
Liver; Hepatocellular Carcinoma; Transarterial Chemoembolization; Clostridium perfringens
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.5 No.12A,
December
31,
2012
ABSTRACT:
A 77-year-old man who
received transarterial chemoembolization
for large hepatocellular carcinomas complained of acute pain in the
upper abdomen and suddenly developed severe jaundice, anemia, and massive hematuria. Abdominal computed tomography demonstrated
gas gangrene at the tumor site. Clostridium
perfringens was identified from blood samples and drainage cultures from
the liver abscess. Despite intensive treatment, the patient died 55 hours
after chemoembolization due to multiple
organ failure. When treating patients with large tumors, such as in our
case, this rare but fatal complication that causes sepsis and hemolysis with
lightning-like rapidity should be considered.