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has been cited by the following article:

• TITLE: Immunohistochemical Evaluation of Vascular Endothelial Growth Factor (VEGF) in Splenic Hemangiomas and Hemangiosarcomas in Dogs

  AUTHORS: Andressa Gianotti Campos, Juliana Alvares Duarte Bonini Campos, Daniel Soares Sanches, Maria Lúcia Zaidan Dagli, Julia Maria Matera

  KEYWORDS: Canine; Spleen; Angiogenesis; Hemangiosarcoma; Immunohistochemistry; Vascular Endothelial Growth Factor

  JOURNAL NAME: Open Journal of Veterinary Medicine, Vol.2 No.4, December 13, 2012

  ABSTRACT: Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P