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has been cited by the following article:

• TITLE: Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution

  AUTHORS: Yui Ogasawara, Yuta Murai, Yasuko Sakihama, Yasuyuki Hashidoko, Makoto Hashimoto

  KEYWORDS: Click Chemistry; Quantitative Determination; Propargylglycine; Cu(I); Buffer

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.3A, November 30, 2012

  ABSTRACT: The click reaction is one of the latest techniques for the functional analysis of bioactive compounds and the analysis makes novel concepts and strategies for medicinal chemistry. N-methylated glycine derivatives have inhibitory activity for the click reaction in direct Cu(I) system because of decrease of Cu(I) concentration. The Cu(I) concentration recovered effectively by sodium ascorbate. Quantitative determination of click reaction at various ligand concentrations revealed that the decrease in reaction yields was observed in a substrate concentration-dependent manner.