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has been cited by the following article:

• TITLE: Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report

  AUTHORS: Heleen Binnenmars, Herman H. D. Idzerda, Hanno L. Tan, Gerard C. M. Linssen

  KEYWORDS: Modafinil; Narcolepsy; Ventricular Tachycardia

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.3 No.6, November 22, 2012

  ABSTRACT: Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.