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Online Mendelian Inheritance in Man (2012). MIM Number: {608232}. Baltimore, MD: Johns Hopkins University. URL (last checked 27 July 2012). http://omim.org/

has been cited by the following article:

  • TITLE: Analogies for Teaching Mutant Allele Dominance Concepts

    AUTHORS: Rebecca L. Seipelt-Thiemann

    KEYWORDS: Analogy; Genetics; Allele Dominance

    JOURNAL NAME: Creative Education, Vol.3 No.6A, October 25, 2012

    ABSTRACT: Analogies connect new and familiar concepts and ideas by providing a comfortable and known framework within which students can integrate new concepts. Use of analogies to aid understanding of abstract and/or complex ideas is commonly used in molecular sciences, such as genetics, molecular biology, and biochemistry. Five analogies for different mechanisms of mutant allele dominance, a seemingly counter-intuitive idea in genetics, were designed and assessed in an upper division undergraduate/masters level course. Each of the five mechanisms, haploinsufficiency, acquired function, poison product, increased activity, and inappropriate expression, was described in the context of a human disease and molecular mechanism and followed by a descriptive analogy which mirrored the molecular mechanism using real world items or a video clip. The majority of students reported increased interest, understanding, and engagement following the analogies, as well as decreased confusion.