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Becker, M. A., Meyer, L. J., & Seegmiller, J. E. (1973). Gout with purine overproduction due to increased phosphoribosyl phosphate synthetase activity. American Journal of Medicine, 55, 232-242. doi:10.1016/0002-9343(73)90174-5 Busciglio, R. (2010). Lucy candy 3. URL. http://www.youtube.com/watch?v=0YGF5R9i53A

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  • TITLE: Analogies for Teaching Mutant Allele Dominance Concepts

    AUTHORS: Rebecca L. Seipelt-Thiemann

    KEYWORDS: Analogy; Genetics; Allele Dominance

    JOURNAL NAME: Creative Education, Vol.3 No.6A, October 25, 2012

    ABSTRACT: Analogies connect new and familiar concepts and ideas by providing a comfortable and known framework within which students can integrate new concepts. Use of analogies to aid understanding of abstract and/or complex ideas is commonly used in molecular sciences, such as genetics, molecular biology, and biochemistry. Five analogies for different mechanisms of mutant allele dominance, a seemingly counter-intuitive idea in genetics, were designed and assessed in an upper division undergraduate/masters level course. Each of the five mechanisms, haploinsufficiency, acquired function, poison product, increased activity, and inappropriate expression, was described in the context of a human disease and molecular mechanism and followed by a descriptive analogy which mirrored the molecular mechanism using real world items or a video clip. The majority of students reported increased interest, understanding, and engagement following the analogies, as well as decreased confusion.