Article citationsMore>>
[12] X. K. Jane, J. S. Martin, A. C. Roland, D. L. Kristin, A. J. Robert, J. Aaron, A. D. Rozalia, J. H. David, W. Rolf and R. Michael, “Design, Synthesis and Evaluation of 10-NSubstituted Acridones as Novel Chemosensitizers in Plasmodium Falciparum,” Antimicrobial Agents and Chemotherapy, Vol. 51, No. 11, 2007, pp. 4133-4140.
has been cited by the following article:
-
TITLE:
3D-QSAR Topomer CoMFA Studies on 10 N-Substituted Acridone Derivatives
AUTHORS:
Adeayo O. Ajala, Cosmas O. Okoro
KEYWORDS:
Acridone; Topomer; Acyclic; CoMFA; Cross-Validated; SAR
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.2 No.3,
September
27,
2012
ABSTRACT: Topomer CoMFA models have been used to optimize the potency of 15 biologically active acridone derivatives se- lected from the literature. Their 3D chemical structures were sliced into three acyclic R groups, to produce a fragment that is present in each training set. The analysis was successful with 3 as the number of components that provided the highest q2 results: q2 is 0.56, which is the cross-validated coefficient for the specified number of components, giving rise to 0.37 standard error of estimate (q2 stderr), and a conventional coefficient (r2) of 0.82, whose standard error of estimate is 0.24. These results provide structure-activity relationship (sar) among the compounds. The result of the To-pomer CoMFA studies was used to design novel derivatives for future studies.