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R. S. Wilson, S. E. Arnold, J. A. Schneider, P. A. Boyle, A. S. Buchman and D. A. Bennett, “Olfactory Impairment in Presymptomatic Alzheimer’s Disease,” Annals of the New York Academy of Sciences, Vol. 1170, 2009, pp. 730-735. doi:10.1111/j.1749-6632.2009.04013.x

has been cited by the following article:

  • TITLE: Modification of the Brief Smell Identification Test by Introduction of a Placebo

    AUTHORS: Grete Kjelvik, Ole Bosnes, Ragnhild Omli, Liv Heidi Skotnes, Asta K. Håberg, Linda R. White

    KEYWORDS: B-SIT; Odor Identification; Scratch and Sniff Tests; Norwegian Population; Olfactory Testing; Neurodegenerative Diseases

    JOURNAL NAME: Neuroscience and Medicine, Vol.3 No.2, June 8, 2012

    ABSTRACT: Objective: To introduce the concept that there might be “nothing to smell” to the Brief Smell Identification Test (B-SIT), with a view to masking olfactory deficits, particularly from healthy control participants in research studies. Methods: Seventy-one elderly individuals, healthy for their age, were recruited to the study. They were blindfolded and carried out a modified B-SIT where one item had been replaced with a placebo, and one odour alternative answer to three other items was replaced by the alternative “none/other” (actual odour unchanged). Results: There was no overall difference in the median or mean score achieved by the cohort compared to results obtained previously using the conventional B-SIT. The replacement of the item “turpentine” with a placebo resulted in an improved score for the item in a Norwegian setting. The overall scores were not improved. Conclusions: It is possible to introduce the concept that there may be “nothing to smell” to the B-SIT without compromising the test for healthy control individuals. This may be a more appropriate approach to olfactory testing of control individuals or patients with suspected early neurodegenerative diseases.