TITLE:
Leukemoid Reaction as a “Tumor Marker” in Breast Cancer
AUTHORS:
Chien-Hua Lin, Jyh-Cherng Yu, Jing-Jim Ou, Yueh-Tsung Lee, Hurng-Sheng Wu
KEYWORDS:
Leukemoid Reaction; Leukocytosis; Breast Cancer
JOURNAL NAME:
Surgical Science,
Vol.3 No.5,
May
25,
2012
ABSTRACT: Neutrophilic leukocytosis above 50 × 109/l exclude leukemia, defines a leukemoid reaction (LR). It is associated with several diseases. Although it simulates leukemia, most of the causes are benign. Tumor-related LR is more common. It is associated with ranulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. A 38-year-old woman, presented with advanced breast cancer and leukocytosis (79.9 × 103/uL) was found. After completion of MRM, the condition of leukocytosis subsided. Two months later, tumor local relapse was found and white blood cells (WBC) rose again. After completion of wide excision, the condition of leukocytosis subsided again. We think this case was associated with leukemoid reaction.