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Article citations


T. Holen, M. Amarzguioui, M. T. Wiiger, E. Babaie and H. Prydz, “Positional Effects of Short Interfering RNAs Targeting the Human Coagulation Trigger Tissue Factor,” Nucleic Acids Research, Vol. 30, No. 8, 2002, pp. 17571766. doi:10.1093/nar/30.8.1757

has been cited by the following article:

  • TITLE: Optimal Immunotherapy Control of Aggressive Tumors Growth

    AUTHORS: Elnaz Keikhosoro Kiani, Ali Vahidian Kamyad, Hedayatollah Shirzad

    KEYWORDS: Aggressive Tumor; Immunotherapy; Optimal Control; AVK Method

    JOURNAL NAME: Intelligent Control and Automation, Vol.3 No.2, May 23, 2012

    ABSTRACT: Tumor cells can evade immune surveillance by secreting immuno-suppressive factors such as transforming growth factor-beta (TGF-β) and also, Interlukin-10 (IL-10). In this paper the optimal control of mathematical model for aggressive tumor growth via a new and proper approach known as AVK method has been considered. Moreover, we have implemented a special treatment so-called small interfering RNA (siRNA) to reduce presence and effect of TGF-β in tumor cells and also we have added Interlukin-2 (IL-2) into our treatment model to minimize the population of tumor cells. Further research and experimentation with these combination therapies may provide an effective solution in addressing the immuno-suppressive effects of TGF-β. Finally, we analyze the optimal control and system optimality of these equations using numerical techniques.