TITLE:
Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease
AUTHORS:
Angelo M. Scanu, Diana M. Stafforini, Celina Edelstein
KEYWORDS:
Plasminogen; Apolipoprotein(a); Lipoprotein(a); Oxidized Phospholipids; Oxidized Phosphatidylcholines
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.2 No.2,
April
28,
2012
ABSTRACT: Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.