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has been cited by the following article:

• TITLE: Determination of 8 Diuretics and Probenecid in Human Urine by Gas Chromatography-Mass Spectrometry: Confirmation Procedure

  AUTHORS: Olga Zaporozhets, Iuna Tsyrulneva, Mykola Ischenko

  KEYWORDS: Diuretics; Urine; Gas Chromatography; Tandem Mass Spectrometry; Confirmation

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.3 No.4, April 17, 2012

  ABSTRACT: A fast and sensitive method for determination of 8 diuretics (acetazolamide, bendroflumethiazide, bumetanide, chlorthalidone, furosemide, hydrochlorothiazide, metolazone, triamterene) and masking agent (probenecid) in human urine using gas-chromatography with mass spectrometric detection is described. The extraction of the substances as function of the nature of organic solvent, mixing time and pH of aqueous phase was studied. The tandem mass spectrometry was used to increase selectivity of diuretics determination due to elimination of background interferences. Fragmentation reactions were studied for each compound and their collision energies were optimized to obtain the best selectivity. The results of method’s validation demonstrate its suitability in routine analysis for confirmation purposes.