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Kane, J.M., Staeger, M.A., Dalton, C.R., Miller, F.P., Dudley, M.W., Ogden, A.M., Kehne, J.H., Ketteler, H.J., McCloskey, T.C. and Senyah, Y. (1994) 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of stry-chnine-induced convulsions and potential antispastic agents. Journal of Medicinal Chemistry, 37, 125-132.
doi:10.1021/jm00027a015
has been cited by the following article:
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TITLE:
Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones
AUTHORS:
Morasa Sheikhy, Amir R. Jalilian, Aytak Novinrooz, Farahnaz Motamedi-Sedeh
KEYWORDS:
Synthesis; Antibacterial; Thiosemicarbazides; Thiosemi-carbazones
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.5 No.2,
February
28,
2012
ABSTRACT: In the present study various thiosemicarbazides and thiosemicarbazones were synthesized and screened for their antimicrobial activity. Among the ligands tested, compounds 1, 3, 4 and 5 demonstrated inhibitory effects at 0.4 - 0.5 μM concentrations against E. coli while 1-(4-fluorobenzoyl)-N4-ethyl-thiosemicar-bazide (3) demonstrated the maximum inhibitory effective compound against E. coli, also possessing high water solubility. Instead, compound 3 demonstrated weak antibiotic effects against S. aurous while compounds 4 - 6 demonstrated significant antibacterial effects at 0.4 - 0.42 μM against the latter organism. Chloramphenicol was used as the positive control.
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