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Pfaller, M.A., et al. (2001) Vitro activities of posaconazole (Sch 56592) compared with those of itraconazole and Fluconazole against 3,685 clinical isolates of Candida spp. and Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy, 45(10), 2862-2864.

has been cited by the following article:

  • TITLE: Treatment of chronic vulvovaginal candidiasis with posaconazole and ciclopiroxolamine

    AUTHORS: Hans-Jürgen Tietz

    KEYWORDS: Chronic Recurrent Vulvovaginal Candidiasis; VVC; Candida Glabrata; Posaconazole

    JOURNAL NAME: Health, Vol.2 No.6, June 28, 2010

    ABSTRACT: Therapy of chronic recurrent vulvovaginal can- didiasis (VVC) caused by Candida glabrata is still rare in comparison to C. albicans infection, but therapy remains more difficult. Combination therapy with topical antifungals may improve therapy outcome, but still standard agents as fluconazole or itraconazole often fail. Posaconazole is a new systemic triazole with a wide antifungal spectrum including rare Candida species. Up to now, no clinical trials with posa- conazole in chronic recurrent VVC have been undertaken. Here, first results of the application of a new therapy regimen consisting of oral posaconazole in combination with topical ciclopiroxolamine are presented. 15 patients with chronic recurrent VVC caused by C. glabrata have been treated. 14 of these patients experienced successful therapy, clinical and mycological cure 30 days after begin of therapy has been observed. Long-term results are promising, as in 4 patients clinical and mycologic cure persists for more than 1 year up to now.