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H. Jin, C. X. Xu, H. W. Kim, Y. S. Chung, J. Y. Shin, S. H. Chang, S. J. Park, E. S. Lee, S. K. Hwang, J. T. Kwon, A. Minai-Tehrani, M. Woo, M. S. Noh, H. J. Youn, D. Y. Kim, B. I. Yoon, K. H. Lee, T. H. Kim, C. S. Cho and M. H. Cho, “Urocanic Acid-Modified Chitosan-Mediated PTEN Delivery via Aerosol Suppressed Lung Tumorigenesis in K-rasLA1 MiceAerosol Delivery of PTEN for Lung Cancer Treatment,” Cancer Gene Therapy, Vol. 15, 2008, pp. 275-283. doi:10.1038/sj.cgt.7701116
has been cited by the following article:
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TITLE:
Reducible Poly (2-Dimethylaminoethyl) Methacrylate-Block-Polyvinylimidazole: Synthesis, Transfection Activity in Vitro
AUTHORS:
Bozhang Yu
KEYWORDS:
Reducible Polymer; Gene Expression; Transfection; Cytotoxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.3 No.1,
January
12,
2012
ABSTRACT: Reducible or imidazolyl polycations of block poly(imidazole/2-dimethyl aminoethyl) are of promising in gene delivery. Dimeric poly(2-dimethyl aminoethyl) methacrylate-block-polyvinylimidazole (rDPDMAEMAIM) and reducible poly (2-dimethylaminoethyl) methacrylate (rDPDMAEMA) with single disulfide bond in the backbone was synthesized by oxidizing their dithioester-terminated polymers. The polyplexes sizes, rDPDMAEMAIM/pDNA and rDPDMAEMA/ pDNA (plasmid DNA) are in the ranges of 100 nm - 150 nm at the weight ratio of 12:1, and the zeta potential of rDPDMAEMAIM/pDNA from 9.6 mV to 22.7 mV in PBS solutions increases with their weight ratios of 1:1 to 18:1. The results show that the rDPDMAEMAIM/pDNA polyplexes have higher transfection activity and lower cytotoxicity than that of rDPDMAEMAIM/pDNA against 293T cells in vitro in the presence of serum, indicating that the PDMAEMAIM present a promising nonviral gene vector.
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