TITLE:
Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers
AUTHORS:
Sommai Patitungkho, Kingkaew Patitungkho
KEYWORDS:
Metal Complexes, Cancers, Antioxidant, Hydrazone, Retinoid Receptors
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.14 No.1,
March
29,
2024
ABSTRACT: This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their in vitro anti-proliferative activities have shown that ligand L1 is effective against human breast cancer BT-20 and MCF-7 cell lines. At the same time, compound L2 exerts its effect on human prostate cancer PC-3 and human breast cancer MDA-MB-231 and MCF-7 cell lines respectively. The retinoid ligands exert their pleiotropic action toward retinoic acid receptors (RARs) than their metal complexes but all compounds exhibit concentration-dependent.