D. S. Prasanna, C. V. Kavitha, K. Vinaya, S. R. Ranganatha, B. Raghava, Y. C. Sunil Kumar, Sathees C. Raghavan, K. S. Rangappa, “Synthesis and Antileukemic Activity of 1-((S)-2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(substituted phenyl)urea Derivatives,” Bulletin of the Chemical Society of Japan, Vol. 83, No. 6, 2010, pp. 689-697. doi:10.1246/bcsj.20090318

has been cited by the following article:

• TITLE: Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents

  AUTHORS: Simin Teimoori, Kuppusamy Panjamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

  KEYWORDS: Cancer Therapy, Cytotoxicity, 1, 4-Diazepane, Isocyanates, Isothiocyanates

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.4, October 12, 2011

  ABSTRACT: In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide / carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 µM.