S. Kato, H. Harada, and T. Morie, “Efficient Synthesis of (6R)-6-Amino-1-methyl-4-(3-methylbenzyl)hexahydro-1H-1,4-diazepine from Methyl (2R)- and (2S)-1-Benzyloxy-carbonylaziridine-2-carboxylates,” Journal of the Chemical Society, Perkin Transactions, Vol. 1, 1997, pp. 3219-3225. doi:10.1039/a703661b

has been cited by the following article:

• TITLE: Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents

  AUTHORS: Simin Teimoori, Kuppusamy Panjamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

  KEYWORDS: Cancer Therapy, Cytotoxicity, 1, 4-Diazepane, Isocyanates, Isothiocyanates

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.4, October 12, 2011

  ABSTRACT: In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide / carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 µM.