Article citationsMore>>
Sacchetti, B., Funari, A., Remoli, C., Giannicola, G., Kogler, G., Liedtke, S., Cossu, G., Serafini, M., Sampaolesi, M., Tagliafico, E., Tenedini, E., Saggio, I., Robey, P.G., Riminucci, M. and Bianco, P. (2016). No Identical “Mesenchymal Stem Cells” at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels. Stem Cell Reports, 6, 897-913.
https://doi.org/10.1016/j.stemcr.2016.05.011
has been cited by the following article:
-
TITLE:
Mesenchymal Stromal Cells and Their Uses in Bio-Regenerative Therapies for Bone and Cartilage: A Review
AUTHORS:
Nathan Smernoff
KEYWORDS:
Mesenchymal Stromal Cells, Osteoarthritis, Non-Unions
JOURNAL NAME:
Open Journal of Regenerative Medicine,
Vol.13 No.1,
March
13,
2024
ABSTRACT: Mesenchymal stromal cells (MSCs) are a top candidate for new clinical treatments in the repair of bone and cartilage. In several clinical trials, they have shown reliable, effective, and safe management of inflammation, pain, and the regenerative capabilities of resident tissues. MSCs are likely derived from pericytes. They modulate the environment they are placed in by secreting immunomodulatory and signaling molecules to reduce inflammation and direct resident cells to create new tissues. They are easily isolated from several different adult tissues, and inexpensive to grow in a lab. However, a mistake made in the initial classification of MSCs as stem cells has created deeply engrained misconceptions that are still evident today. MSCs are not stem cells, despite a large fraction of research and therapies using the name “mesenchymal stem cells”. This mistake creates false narratives attributing the observed positive outcomes of MSC treatments to stem cell characteristics, which has led to distrust in MSC research. Despite inconsistencies in their classification, MSCs demonstrate consistent positive effects in numerous animal studies and human clinical trials for non-unions and osteoarthritis. With an aging population, regenerative techniques are very promising for novel therapies. To produce trusted and safe new treatments using MSCs, it is essential for the International Society for Cellular Therapies to re-establish common ground in the identity, mechanism of action, and isolation techniques of these cells.
Related Articles:
-
Sarah Tasneem, Lester Lipsky, Reda Ammar, Howard Sholl
-
Nike Hendrijantini, Utari Kresnoadi, Sherman Salim, Bambang Agustono, Endang Retnowati, Iwan Syahrial, Pungky Mulawardhana, Manggala Pasca Wardhana, Coen Pramono, Fedik Abdul Rantam
-
Maeda Mohammad, Nahi Yaseen, Ahmad Al-Joubory, Rafal Abdullah, Noah Mahmood, Aesar A. Ahmed, Ahmed Al-Shammari
-
Mahmoud Hashemitabar, Elham Allahbakhshi, Mohamad Reza Tabande, Mahmoud Orazizadeh, Fereshteh Nejad Dehbashi, Saeed Azandeh, Kambiz Ahmadi Engali, Darioush Bijan Nejad
-
Miguel A. Jiménez-Acosta, Lory Jhenifer Rochín Hernández, Mayte Lizeth Padilla Cristerna, José Tapia-Ramírez, Marco A. Meraz-Ríos