TITLE:
Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial
AUTHORS:
Thalita Bandeira Dantas, Alline Peralta Castro, Fernando de Souza Flexa Ribeiro Filho, Rosana Maria Feio Libonati
KEYWORDS:
HIV, Lipodystrophy, Omega-3, Phase Angle
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.15 No.1,
January
23,
2024
ABSTRACT: Objective: The measurement of phase angles is an important monitoring parameter and
supplementation with omega-3 could promote benefits by modulating the
electrical potential of membranes and increasing body cell mass. This study
aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on
the phase angle of people living with HIV/AIDS. Methods: In this study,
63 individuals of all genders who were undergoing outpatient follow-up and
showed lipodystrophy due to highly active antiretroviral therapy were analyzed.
Our sample consisted of two groups, one that received supplementation
containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg
of docosahexaenoic acid) for three months (n = 32) and another that underwent
nutrition guidance (n = 31). Phase angle and body cell mass were assessed for
both groups and compared at the beginning of research (T0) and after our
intervention (T1) for each group separately. Results: Phase angle
averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a
significant increase in phase angle and body cell mass, whereas the guidance
group showed a decrease in body cell mass at T1 in relation to T0, with a
significant p-value. Variance in phase angle between moments showed significant
values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but
we emphasize the need for other studies that can solidify knowledge about
supplementation dosage and intervention time.