TITLE:
Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients
AUTHORS:
Gad Allah Modawe, Ibtihal Elamin Mohammed, Abuagla M. Dafalla, Abdelmarouf Mohieldein
KEYWORDS:
Lipid Peroxide, Malondialdehyde, Hyperglycemia, Type 2 Diabetes Mellitus, Sudanese
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.13 No.12,
December
27,
2023
ABSTRACT: Background
and objectives: Diabetes is a chronic
multifactorial disease which requires
a variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD)
is the most common form of diabetes which results from inefficiency of insulin
secretion or resistance to insulin action, both of which lead to chronic
hyperglycemia. Lipid peroxidation is an oxidative stress process that involve
in T2DM complications. This study aimed to 1) determine plasma malondialdehyde
(MDA) levels as a biomarker for lipid peroxidation in Sudanese patients with
T2DM, and 2) assess the associations between MDA and diabetes-related
variables. Material and Methods: This case-control study was conducted
from November 2022 to June 2023 at the National University, Sudan. It included
100 participants, of whom 50 were T2DM patients and 50 were healthy controls.
Data on demographics, clinical characteristics, and biochemical markers (FBS,
HbA1c, and MDA) were collected. The NycoCard HbA1c method and the GOD-POD
Method were used for HbA1c and glucose measurement, respectively. MDA was
determined by the thiobarbituric acid reactive substances method. The data were
analyzed using SPSS Version. Results: Significant differences were
observed between T2DM patients and healthy controls in FBS (P = 0.000), HbA1c
(P = 0.000), and MDA (P = 0.010), with T2DM patients exhibiting higher levels.
The study revealed a strong positive correlation between MDA levels and the
duration of diabetes (r = 0.69, P = 0.00), while other variables, including
age, BMI, and glucose control, did not significantly correlate with MDA levels. Conclusion: Findings revealed elevated MDA levels in Sudanese T2DM
patients, with a positive correlation between MDA and diabetes duration. These
findings emphasize the importance of oxidative stress in T2DM pathogenesis and
call for the need for targeted strategies to mitigate oxidative damage and
improve diabetes care.