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https://doi.org/10.3892/or.2023.8482

has been cited by the following article:

• TITLE: The Mechanism and Research Progress of Ferroptosis in Esophageal Squamous Cell Carcinoma

  AUTHORS: Jinmeng Gong, Xiaoping Tan

  KEYWORDS: ESCC, Ferroptosis, System Xc?, GPX4, PUFA, MUFA, Fe2+, ROS, Lipid Peroxidation

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.10, October 27, 2023

  ABSTRACT: Esophageal squamous cell carcinoma (ESCC), as the main histological type of esophageal cancer (EC), has the characteristics of high malignant degree, high mortality and tendency to lymph node metastasis. Despite the combination of surgery and chemoradiotherapy, ECSS has a poor prognosis. Ferroptosis is a newly discovered iron-dependent programmed cell death pattern characterized by the accumulation of lipid peroxidation and characteristic morphological changes of mitochondria. It regulates the growth and invasion of cancer cells in various tumors such as gastric cancer and pancreatic cancer. In this article, we mainly introduce the ferroptosis regulatory mechanism in ESCC, hoping to provide a new direction and ideas for the treatment of ECSS.