Ran, L., Chi, Y., Huang, Y., He, Q. and Ren, Y. (2020) Synergistic Antioxidant Effect of Glutathione and Edible Phenolic Acids and Improvement of the Activity Protection by Co-Encapsulation into Chitosan-Coated Liposomes. LWT—Food Science and Technology, 127, Article ID: 109409.
https://doi.org/10.1016/j.lwt.2020.109409

has been cited by the following article:

• TITLE: Electronic Aspects of the Synergistic Antioxidant Interaction of Various Pairs “Phenolic Food Acid and Glutathione” in Their Reactions with the Stable Radical Cation ABTS+·

  AUTHORS: Mikhail Yu. Gorbachev, Natalia N. Gorinchoy, Iolanta I. Balan

  KEYWORDS: Synergistic Effect, Caffeic Acid and Glutathione, ABTS+· Test, Electronic Mechanism, DFT Calculations

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.13 No.3, September 26, 2023

  ABSTRACT: In the present work, for the first time, the main details of the electronic mechanism of the synergistic antioxidant interaction between different pairs: phenolic food acid and glutathione and the stable radical cation ABTS+· were revealed on the basis of a rigorous analysis of the DFT calculated data. It was shown that among all the studied food acids, only caffeic acid exhibits a clear-cut significant synergistic effect with glutathione. It established the electronic and structural factors underlying the mechanism of the synergistic interaction of the mixture caffeic acid and glutathione in its reaction with ABTS+·. The main causes of this considered synergistic effect are, firstly, the presence of the 3-OH and 4-OH hydroxyl groups in the structure of caffeic acid, secondly, the greater stability of its anion which contains the deprotonated 4-OH hydroxyl group. All other phenolic food acids under study do not possess the given structural particularity and therefore do not show such synergistic effects with glutathione.