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https://doi.org/10.1073/pnas.1620079114

has been cited by the following article:

• TITLE: Metabolic Effect of Dietary Erythritol Intake on Escherichia coli

  AUTHORS: Zhaoyue Zhang

  KEYWORDS: Artificial Sweetener, Erythritol, Hemolytic Activity, Escherichia coli

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.13 No.8, August 31, 2023

  ABSTRACT: Artificial sweeteners are man-made substitutes for diet that needs low sugars or caloric intake. Recent studies have shown that AS consumption is possibly associated with metabolic disturbances and intestinal flora disturbances. Erythritol is a kind of 4-carbon sugar substitute in the form of sugar alcohol, which may contribute to the prevention of gingivitis by inhibit the biofilm formation of oral bacteria. Despite these studies, the data on how erythritol affects commensal flora causing pathogenicity to remain limited. In this study, microbiota (Escherichia coli) models were used to investigate the effects of different concentration of erythritol on the metabolism of bacteria, especially on Escherichia coli’s growth, transformation efficiency and hemolytic activity. The results showed that sweeteners decreased the bacteria’s ability to normally grow in higher concentration, and form biofilms to varying degrees. And the addition of erythritol in low concentration may have an effect of promote the growth of Escherichia coli. Habitual consumption of artificial sweeteners in the diet continues to increase was associated with the maintenance of micro-ecological equilibrium in gut.