Bell, D. and Winstanley, P. (2004) Current Issues in the Treatment of Uncomplicated Malaria in Africa. British Medical Bulletin, 71, 29-43. https://doi.org/10.1093/bmb/ldh031

has been cited by the following article:

• TITLE: Visible Malformations in Mice, Mus musculus Experimentally Exposed in Utero to Antimalarials (Manalaria®, Syrup Kilma® versus Quinine)

  AUTHORS: Joseph Kangudia Mbaya, Damien Mbanzulu Pita Nsonizau, Nene Mbanzulu Nsolani, Gauthier Mesia

  KEYWORDS: Embryotoxicity, Mus musculus, Manalaria, Syrup Kilma, Quinine

  JOURNAL NAME: Open Access Library Journal, Vol.10 No.6, June 30, 2023

  ABSTRACT: The antimalarial phytomedicines, Manalaria® and Sirop Kilma®, also frequently used in Kinshasa at the start of pregnancy, would not have previously undergone embryotoxicity tests. This study aims to determine the embryotoxicity of Manalaria® and Sirop Kilma® on mice, Mus musculus. An experimental study in which 54 prepubescent mice were exposed during embryogenesis, including 16 mice to Manalaria®, 20 to Syrup Kilma® and 18 to Quinine. Careful observation by visual inspection and enlarged photography enabled the search for malformations in the exposed mice. As a result, all the mice exposed to the 3 antimalarials did not reveal visible malformations on visual inspection or on enlarged photography. In conclusion, under the experimental conditions of this study, no visible malformation was observed in mice exposed to the two phytomedicines in utero.