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has been cited by the following article:

• TITLE: Potential Application of a Wine Extract in Skin Care: How to Benefit from the Antibacterial, Antioxidant and Elastase Inhibiting Properties

  AUTHORS: Lisa-Marie Sittek, Thomas Michael Schmidts, Peggy Schlupp

  KEYWORDS: Phenolic Wine Extract, Skin Care, HaCaT Cells, Elastase, Lipase, IL-6, IL-8, Cell Proliferation, Reactive Oxygen Species, Antimicrobial, Antimycotic

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.13 No.2, June 19, 2023

  ABSTRACT: Since plant polyphenols have many beneficial properties on health, the aim of this study was to evaluate the potential use of a phenolic wine extract, a by-product of wine production, for skin care on HaCaT cells. In these studies, a significant reduction of reactive oxygen species formation in HaCaT cells and severe elastase inhibition was observed. In contrast, the wine extract caused a major increase in lipase activity. The extract showed no influence on cell proliferation, but an immunomodulatory effect on the release of the interleukins IL-6 and IL-8 was found. The phenolic wine extract demonstrated a strong activity against gram-positive and gram-negative pathogens, yeasts, and fungi. Overall, our results show that the investigated phenolic wine extract is a promising ingredient for anti-aging skin care, could contribute to the improvement of skin appearance and health, and may positively affect cellulite.