TITLE:
Profiling and Determinants of Impaired Lipid Profile Parameters among Breast Cancer Women of Childbearing Age Living in Douala, Cameroon
AUTHORS:
Idriss Ntatou Lemouchele, Suzi Pascale Mbougang, Esther Dina Bell, Loick Pradel Kojom Foko, Eric Fouelifack Nzeko, Cecile Okalla Ebongue, Jean Pierre Nda Mefo’o, Martin Luther Koanga Mogtomo, Rosalie Anne Ngono Ngane
KEYWORDS:
Breast Cancer, Women of Childbearing Age, Lipoprotein, Impairment, Determinants, Cameroon
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.11 No.5,
May
22,
2023
ABSTRACT: Objective: Breast cancer in women of childbearing age (WCBA) is a major public health concern. This study aimed to determine variation and determinants in lipid profile among Cameroonian WCBA diagnosed with breast cancer. Materials and Methods: A case-control study took place at two reference hospitals in Douala, Cameroon. A total of 176 WCBA (88 cases and 88 controls) were finally enrolled. Interviewer-administered questionnaires were used to collect sociodemographic, behavioural, clinical and anthropometric data. Three millilitres of venous blood were collected for analysis of total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and triglycerides (TG). Results: Overweight was predominantly seen in cases and controls. Serum levels of TC and LDL-c were significantly lower in cancer women (167.02 ± 45.46 vs 183.12 ± 27.38 mg/dL, p = 0.005 for TC; 85.83 ± 40.34 vs 105.25 ± 29.95 mg/dL, p = 0.0004 for LDL-c), while HDL-c levels were higher in controls (45.09 ± 7.20 vs 38.24 ± 11.14 mg/dL, p Conclusion: This study suggests the influence of breast cancer on lipid profile parameters especially HDL-c and LDL-c, and possibly their putative clinical utility for early diagnosis in premenopausal women in Cameroon.