Potter, W.Z., Thorgeirsson, S.S., Jollow D.J. and Mitchell, J.R. (1974) Acetaminophen-Induced Hepatic Necrosis V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters. Pharmacology, 12, 129-143.
https://doi.org/10.1159/000136531

has been cited by the following article:

• TITLE: Effects of Sarcocephalus latifolius Fruits Extract on Paracetamol-Induced Liver Damage in Wistar Rats

  AUTHORS: Filkpièrè Léonard Da, Basile Tindano, Géneviève Zabre, Karim Sakira, Balé Bayala, Raymond G. Belemtougri, Philippe Horlait

  KEYWORDS: Rats, Paracetamol, Hepatotoxicity, Sarcocephalus latifolius, Silymarin

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.14 No.4, April 21, 2023

  ABSTRACT: Background and Aim: Sarcocephalus latifolius is a medicinal plant commonly used in traditional medicine to treat various diseases. The aim of the present study is to evaluate the hepatoprotective activity of Sarcocephalus latifolius fruits aqueous extract against paracetamol-induced liver damage in rats. Material and Methods: Aqueous extract of Sarcocephalus latifolius fruits at doses of 100, 250 and 500 mg/kg were administered orally to rats with paracetamol-induced hepatotoxicity (1 g/kg). The treatment with the extract and paracetamol lasted 7 days. Silymarin (50 mg/kg) was given as reference control. All tested drugs were administered orally. Results: Our results show that the Sarcocephalus latifolius fruits extract induced a significant reduction (p Conclusion: Aqueous extract of Sarcocephalus latifolius fruits has hepatoprotective activity against paracetamol-induced hepatotoxicity in rats. But it would be important to evaluate the activity of aqueous extract of Sarcocephalus latifolius fruits on oxidative stress parameters in vivo in rats.