Zhao, X., Kotch, C., Fox, E., Surrey, L.F., Wertheim, G.B., Baloch, Z.W., Lin, F., Pillai, V., Luo, M., Kreiger, P.A., et al. (2021) NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome. JCO Precision Oncology, 5, 204-214.
https://doi.org/10.1200/PO.20.00250

has been cited by the following article:

• TITLE: Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents

  AUTHORS: Tianzhi Zhang, Chao Liang, Guangchang Shan, Danting Su

  KEYWORDS: Children and Adolescents, Thyroid Papillary Carcinoma, Clinicopathological Features, BRAF Mutation

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.14 No.4, April 19, 2023

  ABSTRACT: Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, BRAF mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis; BRAF mutation is less common than in adults.