TITLE:
5-Fluorouracil-Induced Hyperammonemia Encephalopathy in a Patient with Gastric Cancer
AUTHORS:
Toky Rakotoarivo, Vonjy Andrianarison, Ny Ony Andrianandrasana, Malala Razakanaivo, Florine Rafaramino
KEYWORDS:
Encephalopathy, Gastric Cancer, Hyperammonemia, 5-Fluororuracil
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.2,
February
28,
2023
ABSTRACT: Chemotherapy
with 5-fluorouracil (5 FU) has been widely used to treat advanced gastric
cancer. Knowing the side effects is therefore important in order to better
prevent them. Fluoropyrimidine-induced hyperammonemic encephalopathy is a rare
complication and characterized neurological status with elevated ammonia level
without radiological abnormalities. We report the first case of 5 FU-induced
hyperammonemic encephalopathy in women patients on induction chemotherapy for gastric cancer in
Madagascar. His ammonia level (NH3) was 102 μmol/l. The patient
recovered from his confusional state after two days of treatment with
hyperhydration and vitamin therapy.