Takaseya, T., Fumoto, H., Shiose, A., Arakawa, Y., Rao, S., Horvath, D.J., Massiello, A.L., Mielke, N.A., Chen, J.F., Zhou, Q., Dessoffy, R., Kramer, L., Benefit, S., Golding, L.R. and Fukamachi, K. (2009) In vivo biocompatibility evaluation of a new resilient, hard-carbon, thin-film coating for ventricular assist devices. Artificial Organs (in Press).

has been cited by the following article:

• TITLE: In vitro evaluation of a new resilient, hard-carbon, thin-film coating as a bearing material for ventricular assist devices ——In Vitro Bearing Evaluation of BioMedFlex

  AUTHORS: Nicole A. Mielke, Alex L. Massiello, David J. Horvath, Stephen M. Benefit, Darren Burgess, Leonard A. R. Golding, Kiyotaka Fukamachi

  KEYWORDS: Heart Assist Device; Diamond-Like Carbon; Materials Testing; Wear Resistance; Journal Bearing

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.3 No.5, May 27, 2010

  ABSTRACT: Our aim was to evaluate the potential use of BioMedFlex® (BMF), a new resilient, hard-carbon, thin- film coating, as a blood journal bearing material in Cleveland Heart’s continuous-flow left and right ven- tricular assist devices (VADs). BMF is not classified as a diamond-like carbon (DLC) and differs from other thin-film carbon coatings by its high flexural strength, radiopacity, and wear resistance. A 2- to 4-μm-thick BMF adhesion layer was deposited on the VAD journal bearing surfaces. A commercial DLC coating used in other clinical blood pump applications was used as a control. Durability and reliability of the BMF coating was verified in severe pump start/stop testing using 20 BMF-coated journal bearing pairs. The BMF-coated surfaces showed no coating failures, whereas 57% of the DLC bearing pairs developed scratches through the carbon coating, documenting that BMF can provide a durable coating in our blood journal bearing application. In conclusion, BMF has shown qualities that support its significant advantages as an alternative journal bea- ring material in Cleveland Heart pumps. Our plan includes biocompatibility testing with ongoing animal studies, endurance testing with submerged pumps running in saline, and assessment of batch coating processing capability.