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has been cited by the following article:

• TITLE: Spectrum of Neurological Disorders Related to Autoimmune Diseases in Brazzaville, Congo

  AUTHORS: Josué Euberma Diatewa, Ghislain Armel Mpandzou, Rovalez Edgar Mouandza Ongouya, Dinah Happhia Boubayi Motoula-Latou, Karen Lyse Obondzo Aloba, Yacouba Kaba, Régis Moyikoua, Dominique Marline Nguiegna, Estelle Boudzoumou Diakabana, Eliot Prince Galiéni Sounga-Banzouzi, Franck Ladys Banzouzi, Paul Macaire Ossou-Nguiet

  KEYWORDS: Autoimmune Diseases, Neurological Disorders, Brazzaville

  JOURNAL NAME: World Journal of Neuroscience, Vol.13 No.1, February 20, 2023

  ABSTRACT: Background: Autoimmune diseases, which are among the leading causes of morbidity and mortality in the world, are pathologies caused by a dysfunction of the immune system. They can affect the central nervous system, the peripheral nervous system or both nervous systems. Objectives: To describe the epidemiological, clinical, paraclinical, therapeutic and evolutive aspects of neurological disorders related to autoimmune diseases. Methods: This was a prospective cohort study. It was carried out from 1 January 2015 to 31 December 2019 (5 years). It focused on patients aged 15 years and above, who were hospitalized or followed as ambulatory patients for neurological disorders related to autoimmune diseases in the neurology department of the university teaching hospital in Brazzaville. Results: Among the 41 patients who fulfilled inclusion criteria, there were 29 (70.73%) women and 12 (29.27%) men. The average age of patients was 38.3 ± 13.8 years. An increase in the frequency of neurological disorders related to autoimmune diseases was observed every year. The main neurological disorders were neuromyelitis optica spectrum disorders (n = 14; 34.15%), acute polyradiculoneuropathies (n = 13; 31.71%), chronic polyradiculoneuropathies (n = 4; 9.75%) and acute disseminated encephalomyelitis (n = 3; 7.31%). The treatments administered, which consisted of corticosteroids and immunosuppressive drugs, had significantly improved the vital prognosis and functional status of patients (p = 0.025). Conclusion: In our study population, neurological disorders related to autoimmune diseases are rare. The neurological clinico-pathological entities diagnosed are similar to those reported in the literature. The therapeutic approaches used improve the quality of life of patients.