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https://doi.org/10.1016/S0002-9440(10)65131-0

has been cited by the following article:

• TITLE: Bat 26 Microsatellite Instability in Oral Cavity Cancers in Senegal

  AUTHORS: Mame Diarra Samb, Fatimata Mbaye, Mouhamadou Makhtar Ndiaye, Silly Toure, Mbacke Sembene

  KEYWORDS: Cancer, Oral Cavity, Microsatellite Instability, Bat 26, Senegal

  JOURNAL NAME: Journal of Cancer Therapy, Vol.14 No.1, January 12, 2023

  ABSTRACT: Oral cavity cancers are part of head and neck cancers. They have become frequent in the world in general and Senegal in particular. This study evaluates microsatellite instability tumors in oral cavity cancers in Senegal. Forty cancerous tissues, 20 healthy tissues, and 12 blood tissues were included in this study. These tissues were collected from each patient during the biopsy after obtaining consent. DNA extraction, Polymerase Chain Reaction (PCR) and sequencing were carried out to obtain sequences. Mutation surveyor, Bioedit and Dnasp software were used to perform our analyses. High instability was found in 57.5% of patients with cancer. Moreover, 90% of the patients had the same motif on healthy and cancerous tissue. Furthermore, 26.12%, 20.72%, and 11.71% polymorphic sites were found in cancerous, healthy and blood tissue respectively. Thus, a similarity between cancerous and healthy tissues seems to exist. This implies that instability of the Bat 26 microsatellite could occur early in the occurrence of oral cavity cancers.