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https://doi.org/10.1159/000314369

has been cited by the following article:

• TITLE: In Vivo Observation of Allergic Dermatitis of the Genuine Pig by Optical Coherence Tomography

  AUTHORS: Masato Ohmi, Yuki Yoshida, Yoken Son, Kohji Abe

  KEYWORDS: OCT, Allergic Dermatitis, In Vivo Observation, Thickening of Epidermis

  JOURNAL NAME: Modern Research in Inflammation, Vol.11 No.1, February 28, 2022

  ABSTRACT: In order to understand pathogenic mechanism of allergic dermatitis, it is important to find morphological changes of the internal structure of the skin by non-invasive imaging. Optical coherence tomography (OCT) is powerful tool for in vivo tomographic imaging of the internal microstructure in biological tissue. In this study, we prepared the animal model of genuine pig with allergic dermatitis developed by chemical administration to examining their skin inflammation by microscopic observations with OCT images captured continuously, aiming at tracking the morphological changes in the skin structure induced by the chronological inflammation. As a result, epidermis thickening became evident as the days passed since Day 7, and the capillary vessel expansion was confirmed since Day 14; the process of inflammation development was successfully observed.