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https://doi.org/10.1074/jbc.274.5.2829

has been cited by the following article:

• TITLE: MiRNA-181d Is Involved in CREB1 Expression in PC12 Cells

  AUTHORS: Jia Yang, Yueyang Yu, Bo Su, Yun Zheng, Yang Liu

  KEYWORDS: miR-181d, CREB1, PC12 Cells

  JOURNAL NAME: Yangtze Medicine, Vol.6 No.2, June 23, 2022

  ABSTRACT: MicroRNAs are involved in regulation of the central nervous system (CNS) development, and miR-181d highly expressed in mature neurons. CREB is many signal pathways converged point in hippocampal neurons, and it plays a crucial role in learning and memory. In this study, we detected the negative relationship between CREB1 protein and miR-181d expression in lewis rat hippocampus development. And the bioinformatic analysis showed that, CREB1 mRNA contains complementary sequence to the miR-181d seed region. Then we further demonstrated that miR-181d controls the expression level of CREB1 gene in PC12 cells by luciferase assay and western blot. Taken together, our data demonstrated that CREB1 mRNA is the target gene of miR-181d, and conformed CREB1 protein expression was regulated by miR-181d in PC12 cells.